Continuous Glucose Monitor Predicts Glycemic Variability in High-Risk Individuals with HbA1c < 5.7%

Objective: Glycemic variability (GV) and 1 hour plasma glucose (1-h PG) ≥ 8.6 mmol/L during a 75-gram oral glucose tolerance test (OGTT) are associated with increased risk for type 2 diabetes (T2D). GV may be overlooked in high-risk individuals. The objectives of this study are: (1) to determine if continuous glucose monitoring (CGM) using the Abbott Freestyle Libre Pro can replace the OGTT in high-risk subjects with HbA1c Methods: Subjects were recruited with a HbA1c Results: The 1-h PG correlated significantly with CGM glucose levels (r=0.883, p Conclusions: The 1-h CGM glucose and elevated GV indices significantly correlate with 1-h PG (\u003e 8.6 mmol/L) in high-risk subjects with HbA1c Disclosure B. Dorcely: None. E. Sifonte: None. A. Divakaran: None. K. Katz: None. R. Jagannathan: None. I.J. Goldberg: None. M. Bergman: None. Funding Abbott Diabetes Care; New York University Clinical and Translational Science Award (UL1 TR001445)