Diabetes-Related Quality of Life Assessment in Children following Total Pancreatectomy with Islet Autotransplantation
Diabetes(2023)
摘要
Total pancreatectomy with islet autotransplantation (TPIAT) can improve pain and reduce functional impairment associated with acute recurrent or chronic pancreatitis. However, long-term glucose monitoring and insulin therapy are often required, which can adversely affect the quality of life. We sought to evaluate diabetes-related quality of life (DR-QOL) in youth who underwent TPIAT and compare it to the youth with new-onset type 1 diabetes (T1D). The Pediatric Quality of Life Inventory (TM) 3.2 Diabetes Module (PedsQL (TM) DM) was used to assess DR-QOL in 46 youth (<20 years old) who underwent TPIAT. The PedsQL<(TM)> DM scores were analyzed for statistically significant changes and minimally important clinical differences (MCID) over time post-TPIAT. Scores at 12 months (n = 29) and 24 months (n = 16) were then compared to PedsQL (TM) DM scores from a historical cohort of demographically similar (age and sex) youth with a 12 months (n = 52) and 24 months (n = 58) after diagnosis of T1D. The diabetes symptoms summary score (mean 65 to 57 and p=0.03) and the total score (mean 74 to 68 and p<0.05) decreased (worsened) during the first 24 months post-TPIAT and met the MCID threshold, suggesting the decrease in these scores was clinically significant. Post-TPIAT PedsQL<(TM)> DM scores were not significantly different than youth new diagnosis of T1D after 24 months (all p>0.2). In youth who underwent TPIAT, DR-QOL worsened over the first two years, mostly attributable to the diabetes symptoms score. Compared to children with T1D, post-TPIAT DR-QOL was similar two years after diabetes onset.
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关键词
total pancreatectomy,life assessment,diabetes-related
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