Su1578 POST ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS PREVENTION USING TOPICAL EPINEPHRINE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Multiple drugs and techniques have been studied for the prevention of PEP. Topical epinephrine has recently been studied for the prevention of PEP and theoretically should work similarly as a PD stent. Topical epinephrine sprayed on the ampulla can reduce edema by arteriolar vasoconstriction and therefore improve pancreatic outflow. Evidence regarding the use of topical epinephrine in the prevention of PEP is inconsistent with some studies favoring their use while other studies did not show any benefit.