阻塞性睡眠呼吸暂停低通气综合征患者血清Chemerin、Apelin水平与胰岛素抵抗关系研究
Chinese Journal of Asthma(2014)
Abstract
目的 探讨男性OSAHS患者血清Chemerin、Apelin水平与胰岛素抵抗的关系.方法 选择OSAHS患者65例和健康对照组28例,分别采用酶联免疫吸附法测定所有研究对象血清Chemerin、Apelin水平,应用稳态模型评估胰岛素抵抗指数(HOMA-IR).结果 与对照组比较,OSAHS患者血清Chemerin、Apelin水平及HOMA-IR均高于对照组(P值均<0.05).血清Chemerin和Apelin-12水平与AHI呈正相关(r=0.541和0.506,P<0.01),与LSaO2和MsaO2均呈负相关(r=-0.451,-0.401和-0.428,-0.385,P值均<0.01).血清Chemerin和Apelin 12水平与HOMA-IR呈正相关(r=0.438和0.375,P<0.05),血清Chemerin与血清Apelin-12水平两者呈正相关(r值=0.511,P<0.01).患者HOMA-IR变化与AHI、LSaO2、血清Chemerin和Apelin-12水平呈线性回归关系.结论 OSAHS患者血清Chemerin、Apelin水平与胰岛素密切相关,同时与患者严重程度和低氧相关.
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Key words
Obstructive sleep apnea syndrome,Insulin resistance,Chemerin,Apelin
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