小半夏汤类方防治延迟性化疗性呕吐的药效及机制研究
Traditional Chinese Medicine(2020)
Abstract
目的:观察小半夏汤类方对顺铂诱导的大鼠延迟性化疗性呕吐的药效,探讨其作用机制。方法:将60只Wistar大鼠按随机数字表法分为空白组、模型组、昂丹司琼组、小半夏汤组、生姜半夏汤组和半夏干姜散组,每组10只。昂丹司琼组灌胃盐酸昂丹司琼注射液2.6 mg/(kg·d),小半夏汤组灌胃小半夏汤水煎液22 g/(kg·d),生姜半夏汤组灌胃生姜半夏汤水煎液31.5 ml/(kg·d),半夏干姜散组灌胃半夏干姜散水煎液0.63 g/(kg·d),空白组和模型组灌胃等体积生理盐水。每天灌胃2次,连续给药3 d。首次给药后1 h,除空白组外,其余各组大鼠腹腔注射6 mg/kg顺铂建立化疗性呕吐模型。每24 h称量大鼠高岭土摄入量,采用ELISA法检测大鼠回肠和延髓5-羟色胺(5-hydroxytryptamine, 5-HT)、5-羟色胺吲哚乙酸(pentahydroxytryptamine indoleacetic acid, 5-HIAA)、色氨酸羟化酶(trptophan hydroxylase, TPH)、单胺氧化酶A(monoamine oxidases A, MAOA)水平。结果:与模型组比较,小半夏汤组、生姜半夏汤组、半夏干姜散组大鼠回肠和延髓5-HT[回肠(308.04±29.90)ng/L、(355.97±19.16)ng/L、(389.97±24.86)ng/L比(498.95±13.92)ng/L,延髓(375.32±19.33)ng/L、(395.18±16.12)ng/L、(406.68±12.09)ng/L比(478.52±13.88)ng/L]水平均降低(
P<0.05),小半夏汤组回肠TPH[(35.14±2.68)ng/L比(47.31±0.83)ng/L]水平降低(
P<0.05),生姜半夏汤组、半夏干姜散组延髓TPH[(33.68±2.79)ng/L、(38.19±1.74)ng/L比(43.68±1.53)ng/L]水平降低(
P<0.05),小半夏汤组、生姜半夏汤组、半夏干姜散组大鼠回肠和延髓MAOA、5-HIAA水平均降低(
P<0.05)。
结论:小半夏汤类方可有效防治大鼠延迟性化疗性呕吐,其机制可能与降低TPH水平、抑制5-HT合成有关。
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Key words
Xiao Ban Xia Tang,Chemotherapy-induced vomiting,5-hydroxytryptamine,Tryptophan hydroxylase,Rats
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