胆管癌TMS1/ASC基因甲基化及其临床意义
Chinese Journal of Hepatobiliary Surgery（2007）
Abstract
肿瘤发生是多基因协同作用、多因素共同参与、综合发展的结果.研究发现肿瘤抑制基因失活与其启动子区域表遗传性改变即CpG岛甲基化状态直接关联;因此CpG岛甲基化在肿瘤发生、发展过程中发挥着关键作用.
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Key words
cholangiocarcinoma gene tms1/asc,methylation
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