Structural basis for the catalytic activities of the multifunctional enzyme quinolinate synthase

Coordination Chemistry Reviews（2020）

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摘要

•The resolution of omit electron density maps conditions structural interpretations.•Quinolinate synthase displays multifunctional catalytic properties.•Active site cavity dimensions are modulated by substrate binding.•[4Fe-4S] cluster discriminates the binding of two similar substrates.

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关键词

NAD synthesis,[4Fe-4S] Lewis chemistry,X-ray crystallography,Catalytic intermediates,Quinolinate synthase inhibitors

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