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HEMA/NIPAAm栓塞颅底血管网的动物实验研究

Fu-shun XIAO, Zhi-fen NING,Mu LI,Guang CHEN,Xue-quan FENG,Song WANG, Wen-guang LIU,Feng-ying DAI

Chinese Journal of Neurosurgery（2008）

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Abstract
目的 探讨温度敏感型甲基丙烯酸-2-羟乙酯/N-异丙基丙烯酰胺(HEMA/NIPAAm)嵌段共聚物栓塞AVM的动物模型的可行性;评价其栓塞效果及病理改变.方法 选取实验用猪16只.应用微导管超选择性导入猪的颅底血管网(RMB).注射1:1浓度的HEMA/NIPAAm嵌段共聚物、欧乃培克混合物直至RMB完全不显影为止.于术后急慢性期进行造影及病理组织学观察. 结果HEMA/NIPAAm嵌段共聚物在畸形团内弥散和铸型良好,无粘管.血管造影复查未见血管再通.病理检查可见血管团的血管结构消失,周围有异物巨细胞浸润.结论 HEMA/NIPAAm嵌段共聚物栓塞AVM具有弥散佳、无粘管、容易控制、不受注射时间限制、无再通等特点.可以作为临床应用.
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Key words
Central nervous system vascular malformations,Temperature-varied,Embolization material,Embolism
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