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Notch信号通路在肺癌和肺癌干细胞中的作用及其抑制剂

Hengyao Liu,Guoli Zhao,Fuwen Wang,Haibo Cai,Yueying Zhang

Journal of International Oncology（2018）

Cited 2|Views2
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Abstract
Notch信号通路参与肺癌干细胞的异常分化和自我更新,深入研究Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新的靶点.作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物.肺癌干细胞被认为是肺癌复发的主要因素,因此针对肺癌干细胞的靶向治疗可能比针对整个肿瘤的治疗更有效.
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Key words
Receptors,Notch,Lung neoplasms,Neoplastic stem cells,Inhibitors
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