Relationship between gut microbiota and healthy aging: Research progress and future prospective

Gut microbiota, as the most important part of human microbial ecosystem, develops with aging.For the past few years, increasing studies focused on the potential association of microbiota with diseases and health of the total elderly population and found that multiple factors such as ageing, multiple medications, life style, diet, etc.effectively affected the changes of gut microbiota.The changes of gut microbiota could be used in the future as a target for the comprehensive assessment, dynamic surveillance or intervention therapy of frailty, sarcopenia and chronic diseases.Therefore, this review focused on gut microbiota composition, influencing factors of gut microbiota, the feature of gut microbiota in common geriatric diseases, microbiota-based interventions therapy and the longevity microbial resources. Key words: Gut microbiota; Aging; Longevity