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乳腺导管原位癌与导管原位癌伴微浸润的临床比较

Liu Weixin,Wang Shulian,Tang Yu,Jing Hao,Wang Jianyang,Zhang Jianghu,Jin Jing,Song Yongwen,Wang Weihu,Liu Yueping, Fang Hui,Ren Hua,Qi Shunan,Lu Ningning,Tang Yuan,Li Ning,Li Yexiong

Chinese Journal of Radiation Oncology（2020）

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Abstract
目的 分析乳腺导管原位癌(DCIS)及原位癌伴微浸润(DCIS-MI)患者治疗模式变化、临床特征、治疗结果及预后因素.方法 回顾性分析中国医学科学院肿瘤医院1999-2013年收治的866例女性患者资料.DCIS患者631例,DCIS-MI患者235例.用Kaplan-Meier法计算局控(LC)、无瘤生存(DFS)、总生存(OS)率,并Logrank检验和单因素预后分析.结果 DCIS及DCIS-MI两组之间OS、LC及DFS相近(P＞0.05).单因素分析显示Her-2阳性为OS及DFS影响因素,保乳未放疗患者LC和DFS劣于全乳切除术患者.结论 导管原位癌和导管原位癌伴微浸润总体生存结果类似,Her-2阳性为OS及DFS预后不良因素,保乳未放疗患者的LC和DFS劣于全乳切除术.
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Key words
Breast ductal carcinoma in situ,Breast ductal carcinoma in situ with microinvasion,Breast neoplasm/radiotherapy,Breast neoplasm/surgery,Prognosis
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