Clinical significance and the expression of P16 protein and survivin protein in endometrial carci-noma

Objective To study the clinical significance and the expression of P16 protein and survivin protein in endometrial carcinoma. Methods Patients were divided into the normal endometrium group（50 cases）,simple or complex endometrial hyperplasia group（50 cases）,atypical endometrial hy-perplasia group（50 cases）and endometrial cancer group（50 cases）. The expression levels of P16 protein and survivin protein and in different clinical and pathological stages among the groups were compared. Results Compared with other three groups,the levels of P16 protein in endometrial cancer group were significantly lower,the differences were statistically significant（P 〈 0. 05）. Compared the survivin posi-tive expression rate and strong positive expression rate in atypical endometrial hyperplasia group and en-dometrial cancer group with other two groups,the differences were statistically significant（P 〈 0. 05）. The positive expression of P16 protein in Ⅱ-Ⅳ period cases of endometrial carcinoma,higher pathologi-cal grade cases,deep myometrial invasion cases and recurrence cases was significantly lower. The strong-ly positive expression of survivin protein in Ⅱ - Ⅳ period cases,G3 cases,deep myometrial invasion ca-ses and recurrent cases was significantly higher. Conclusions P16 protein has the significance of guid-ance for the surgical pathological staging and judgement of the prognosis. Survivin protein has important significante in the early diagnosis and prognosis judgement of endometrial carcinoma.\r\n\r\nKey words: \r\nP16 protein; Survivin protein; Endometrial cancer