Expressions and clinical significance of SOCS-1 and SOCS-3 in Nephroblastoma

Objective To investigate the expression levels of suppressor of cytokine signaling-1 and suppressor of cytokine signaling-3 in the Wilms\u0027 tumor and to study the inherent relationship between the different pathological types. Methods The expression levels of SOCS-1 and SOCS-3 were assessed by RT-PCR and Western-Blot in ten normal kidney tissues, thirty nephroblastoma specimens and adjacent tissues. Results Compared to the normal kidney tissues(mRNA expressions: 0.721±0.183、0.694±0.148,protein expressions:0.746±0.168、0.652±0.183), the expressions of mRNA (0.156±0.027、0.103±0.021)and protein(0.205±0.079、0.185±0.041)of the SOCS-1 and SOCS-3 in nephroblastoma were significantly lower (P＜0.01). There were statistically significant between mRNA expressions and the different pathological types(FH:0.175±0.086,0、149±0.100,UH:0. 128±0.074、0.091±0.067) (P＜0.05).The difference betweenneuroblastoma and the normal tissues in expressions of mRNA (0. 572 ± 0. 154、0. 315 ± 0. 137)and protein(0. 628± 0. 183、0. 439 ± 0. 137)of the SOCS-1 and SOCS-3 were statistically significant (P＜0. 05). Conclusions The low SOCS-1 and SOCS-3 expressions may have a role in the development and progress of nephroblastoma, and the different pathological types.\r\n\r\nKey words: \r\nNephroblastoma; SOCS-1; SOCS-3