Trefoil factor 1 andgastric cancer

：Trefoil factor 1 (TFF1)is mainly expressed in the mucosa lining the gastrointestinal tract. Changes of itsexpression in gastric cancer tissue play dual roles of carcinogenesis and anti- canceraction involved in modifying the genetic structure,delaying the transition of cellcycle,signal transduction,suppressing cell apoptosis and interaction withcyclooxygenase-2,but the specific mechanism is still unclear. Certain advances have beenmade on the diagnosis and therapy of gastric cancer.