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黑色素瘤特异性抗原基因定量检测在急性髓系白血病及微小残留病监测中的应用

Shufen Hu,Dongmei Tan,Weicheng Xie,Ting Pang,Zhiwei Liu,Puzhao Wu

Journal of Leukemia and Lymphoma（2015）

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Abstract
目的 探讨黑色素瘤特异性抗原(PRAME)mRNA在初诊急性髓系白血病(AML)患者中的表达,评估其在微小残留病(MRD)监测中的作用.方法 收集63例初诊AML患者骨髓标本,并在28个月内追踪了11例患者的34份样本,用Taqman探针的荧光定量PCR技术检测PRAME mRNA的表达.结果 初诊患者中PRAME基因表达阳性率52.4 ％(33/63),不同类型的AML中PRAME基因表达以M3最高;治疗缓解后PRAME基因转阴,形态学复发前数月可检测到PRAME mRNA的升高.结论 PRAMEmRNA在AML中高表达,可作为一个广谱的白血病标志物,用于MRD的监测.
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Key words
Leukemia,acute,myeloid,Minimal residual disease,Preferentially expressed antigen of melanoma,Real-time quantitative PCR,Monitoring
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