Significance of SATB-1 expression in prostate carcinoma

Objective To investigate the expression of special AT rich sequence binding protein (SATB-1) in prostatic carcinoma.Methods Expression of SATB-1 was examined in 90 paraffin-embedded tissue sections including 60 cases of prostatic carcinoma and 30 cases of benign prostate hyperplasia by immunohistochemical staining.The relationship between SATB-1 expression and clinicopathological features was analyzed by Chi-square test.Results The immunohistochemistry revealed that the positive rate of SATB-1 in 60 of prostatic carcinoma was 86.7% (52/60),30 of benign prostate hyperplasia was 0 (0/30).The score of staining intensity of SATB-1 in benign prostate hyperplasia samples,prostatic carcinoma samples without bone metastasis and with bone metas tasis were gradually increasing significantly.The difference among the pathological Gleason score was statistically significant.Conclusion Expression of SATB-1 has close relations with the occurrence and development of prostatic carcinoma.It is hopeful that SATB-1 can be used as one of the indexes to predict early metastasis. Key words: SATB-1; Prostatic carcinoma