CodeBreak 100: Activity of AMG 510, a novel small molecule inhibitor of KRASG12C, in patients with advanced colorectal cancer.

Marwan Fakih,Jayesh Desai,Yasutoshi Kuboki,John H. Strickler,Timothy Jay Price,Greg Andrew Durm,Gerald Steven Falchook,Crystal S. Denlinger,John C. Krauss,Geoffrey Shapiro,Tae Won Kim,Keunchil Park,Andrew L. Coveler,Pamela N. Munster,Bob T. Li,June Kim,Haby Adel Henary,Gataree Ngarmchamnanrith,David S. Hong

Journal of Clinical Oncology（2020）

引用 28|浏览43

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摘要

4018Background: Kirsten rat sarcoma viral oncogene homolog (KRAS) p.G12C mutation is associated with poor prognosis in colorectal cancer (CRC). AMG 510 is a first-in-class small molecule that speci...

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关键词

advanced colorectal cancer,colorectal cancer,novel small molecule inhibitor,amg

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