叶黄素和玉米黄质治疗年龄相关性黄斑变性的多焦视网膜电图变化观察
Chinese Journal of Practical Ophthalmology(2010)
Abstract
目的 应用多焦视网膜电图(multifocal electroretinography,mfERC)评价叶黄素(lutein)和玉米黄质(zeaxanthin)治疗年龄相关性黄斑变性(age-related macular degeneration,ARMD)的视网膜功能变化情况.方法 ARMD患者6例9只眼在接受叶黄素和玉米黄质治疗前及治疗后100d分别对各患眼5个环状视网膜区域进行b波反应密度的测量比较.记录以黄斑中心凹为中心呈同心圆排列的5个环区,自内至外分别是1环(2.18度),2环(7.46度),3环(12.36度),4环(19.66度)和5环(29.75度)的b波反应振幅密度,应用EPi Info统计软件中两个独立样本的t检验进行统计学分析.结果 9只眼ARMD患者治疗前后mf-ERG b波反应振幅密度比较,1,2,3,4,5环各环的振幅密度均明显提高,与治疗前相比差异具有统计学意义(P<0.05).结论 mf-ERG 显示叶黄素和玉米黄质治疗能有效提高ARMD患者mf-ERG的b波反应振幅密度,改善患眼视网膜光感受器功能.
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Key words
Multifocal electroretinography,Lutein,Zeaxanthin,Age-related macular degeneration
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