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EGFR信号通路激活介导中枢神经系统炎症损伤的机制研究进展

Xiaojun Cai,Zheng Jiao,Bingyan Ren,Yi Lu,Xiuhong Zhang,Hao Wen,Shourong Lu,Zaiwang Li

Chinese Journal of Neuromedicine（2018）

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Abstract
脑缺血、脑肿瘤、脊髓损伤等是发病率较高的中枢神经系统疾病,常造成不可逆、严重的神经功能缺损或死亡.炎症反应在中枢神经系统损伤后的继发性损伤中起着重要作用,而表皮生长因子受体(EGFR)过度活化与炎症反应的发生发展密切相关.本文围绕EGFR信号通路激活介导中枢神经系统炎症损伤的机制的最新研究进展综述如下.
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Key words
epidermal growth factor receptor,epidermal growth factor,inflammatory damage,growth factor,pathway activation
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