SOX13抗体对急性起病自身免疫糖尿病的诊断意义
Chinese Journal of Endocrinology and Metabolism(2005)
Abstract
目的探讨SOX13抗体(SOX13-Ab)对急性起病自身免疫糖尿病的诊断价值.方法 162例急性起病糖尿病患者根据谷氨酸脱羧酶抗体(GAD-Ab)和蛋白酪氨酸磷酸酶抗体(IA-2Ab)阳性与否分为经典[GAD-Ab和(或)IA-2Ab阳性]和非经典1型糖尿病(DM)(GAD-Ab和IA-2Ab均阴性)两亚组,正常对照组120名,分析SOX13-Ab分布规律、该抗体阳性患者临床特征及其对胰岛功能的影响.结果 (1)急性起病组和经典1型DM亚组SOX13-Ab阳性率均高于正常对照组(9.3% vs 2.5%,9.9% vs 2.5%;均P<0.05);SOX13-Ab(+)/GAD-Ab(+)双阳性者 6例(3.7%),无1例SOX13-Ab(+)/IA-2Ab(+)双阳性者;(2)SOX13-Ab分布峰值处于发病年龄61~70岁;(3)SOX13-Ab单一阳性组临床特征(包括代谢综合征相关指标异常程度等)与GAD-Ab、IA-2Ab单一阳性和抗体阴性组间差异无统计学意义(P>0.05);(4)SOX13-Ab单一阳性组C肽介于GAD-Ab、IA-2Ab单一阳性和抗体阴性组之间.结论 SOX13-Ab检测可提高诊断急性起病自身免疫糖尿病的敏感性.
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Type 1 Diabetes
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