替比夫定阻断乙型肝炎病毒母婴垂直传播对孕妇、脐带以及新生儿血浆白介素-17A、-10、-6的影响
Chinese Journal of Primary Medicine and Pharmacy(2015)
Abstract
目的:探讨替比夫定用于乙型肝炎(乙肝)病毒母婴垂直传播阻断方案对乙肝孕妇外周血、脐带血、新生儿外周血血浆白介素-17A(IL-17A),白介素-10(IL-10),白介素-6(IL-6)的影响。方法选择住院分娩的孕妇85例[替比夫定组25例,高病毒组,阴性组,非感染组(健康孕妇)各20例],前瞻性分析利用CBA技术测定不同组的孕妇外周血、脐带血、新生儿外周血血浆IL-17A,IL-10,IL-6的表达水平。结果替比夫定组孕妇外周血、脐带血、新生儿血IL-17A的水平[(15.29±4.80)pg/mL、(19.45±4.80)pg/mL、(17.32±4.18)pg/mL]低于高病毒组[(26.03±4.88)pg/mL、(34.07±5.59)pg/mL、(24.12±4.76)pg/mL],差异均有统计学意义(P=0.000,0.001,0.019);替比夫定组孕妇外周血、脐带血、新生儿血IL-10的水平[(6.08±1.32)pg/mL、(2.33±0.68) pg/mL、(3.74±0.61) pg/mL]高于高病毒组[(3.95±1.21) pg/mL、(1.71±0.53)pg/mL、(2.22±0.55)pg/mL],差异均有统计学意义(P=0.023,0.015,0.012);替比夫定组孕妇外周血、脐带血、新生儿血的IL-6的水平较高病毒组下降,差异均有统计学意义(均P<0.05)。结论替比夫定不仅抑制了乙肝孕妇HBV的复制,同时可能部分纠正了乙肝孕妇的免疫失衡,利于妊娠维持。
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Key words
telbivudine,maternal plasmaumbilical,perinatal transmission,plasmaumbilical plasmaumbilical
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