EVI1基因阳性儿童慢性粒细胞白血病加速期一例并文献复习
Cancer Research and Clinic（2019）
Abstract
目的 提高对EVI1基因阳性的儿童慢性粒细胞白血病加速期(CML-AP)的认识.方法 回顾性分析青岛市妇女儿童医院2019年1月收治的1例EVI1基因阳性的儿童CML-AP患者的临床资料,并复习相关文献.结果 患儿,男性,14岁,确诊后,加用国产伊马替尼联合小剂量化疗方案,达血液学完全缓解.BCR-ABL p210定量降至4.66％,EVI1定量降至正常(0.01％).结论 儿童CML-AP罕见,临床特征主要为白细胞计数明显升高和巨脾.国产伊马替尼联合小剂量化疗方案对EVI1基因阳性的儿童CML-AP治疗有效,远期疗效尚需密切随访.
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Key words
chronic myeloid leukemia,evi1
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