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阻塞性睡眠呼吸暂停低通气综合征动物模型的建立及评估方法

Fangfang Zou,Xiaoli Su

Chinese Journal of Asthma（2017）

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Abstract
OSAHS主要特征为睡眠中反复上气道完全或不完全塌陷,随着生活水平的增高,OSAHS发病率逐年增高,在OSAHS的发病机制、并发症及其治疗方法的研究中,动物模型的成功建立至关重要.本文将OSAHS动物模型的建立方法分类总结后归纳为:间歇缺氧法、上气道阻塞法、片段睡眠法,并对其适用动物及评估方法进行了评价和分析.
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Key words
Obstructive sleep apnea-hypopnea syndrome,Intermittent hypoxia,Sleep fragmentation,Airway obstruction,Animal model
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