Consensus Molecular Subtype (Cms) As A Novel Integral Biomarker In Colorectal Cancer: A Phase Ii Trial Of Bintrafusp Alfa In Cms4 Metastatic Crc.

Amir Mehrvarz Sarshekeh,Michael Lam,Isabel R. Zorrilla,Emma Brey Holliday,Prajnan Das,Bryan K. Kee,Michael J. Overman,Christine Megerdichian Parseghian,John Paul Y.C. Shen,Alda Tam,Edwin Roger Parra Cuentas,Liren Zhang,Xuemei Wang,Dzifa Yawa Duose,Rajyalakshmi Luthra, Neelima Reddy,Dipen M. Maru,Scott Kopetz,Van K. Morris

JOURNAL OF CLINICAL ONCOLOGY（2020）

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摘要

4084Background: Consensus Molecular Subtype 4 (CMS4) colorectal cancer (CRC) features increased TGFβ signaling, which may account for de novo resistance to immunotherapy for patients (pts) with mic...

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