实时灰阶超声造影评价肝癌动物模型抗血管生成治疗的研究

Pei-li FAN,Hong DING,Xiao-dong ZHU,Xi-yuan LIN,Ju-bo ZHANG,Wen-ping WANG,Hui-chuan SUN

Chinese Journal of Ultrasonography（2009）

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Abstract

SI)、曲线下面积(AUC)和血流量系数(BF)明显低于对照组,另外峰值减半斜率(a2)和曲线上升斜率(a3)明显大于对照组(P<0.05).定量参数与肿瘤体积增长率正相关(P<0.05).a3和ISI与坏死指数负相关(r=-0.54,P=0.008;r=-0.46,P=0.027).结论实时灰阶超声造影能反映肿瘤内血流灌注变化,有助于监测肿瘤抗血管生成治疗的血管反应.

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Key words

Ultrasonography,Microbubbles,Liver neoplasms,experimental,Neovascularization,pathologic

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