替米沙坦对输尿管梗阻大鼠水代谢紊乱的保护作用
Chinese journal of experimental surgery(2013)
Abstract
目的 观察替米沙坦对双侧输尿管梗阻(BUO)大鼠水电解质紊乱和肾脏水通道蛋白2(AQP2)表达的影响.方法 慕尼黑大鼠36只,随机分为BUO组、替米沙坦组(TEL组)和对照组(Sham组),每组12只.BUO组和TEL组均行双侧输尿管结扎术,Sham组仅游离输尿管但不结扎.TEL组每天TEL液灌胃[5 mg/(kg·d)],BUO组和Sham组同体积生理盐水灌胃.双侧输尿管梗阻24 h后解除梗阻,第4天收集血液和肾脏标本,采用免疫组织化学和Western blot技术检测肾脏AQP2表达.结果 BUO组与Sham组比较,尿量显著增高[(93 6) μl/(min· kg)比(26 ±4)μl/(min· kg)],尿比重和尿钠显著降低[1.007±0.007比1.024±0.017;(43.25±6.99) mmol/L比(182.37±17.91) mmoL/L],血肌酐和血清钾显著增高[(66.22±6.03) μmol/L比(33.89 2.97)μmol/L; (5.57 0.37) mmol/L比(4.29±0.09) mmol/L].TEL组与BUO组比较,尿量显著降低(54 6) μl/(min·kg)比(93 6) μ1/(min· kg),尿比重和尿钠显著升高[1.017 0.009比1.007±0.007;(82.23±12.98) mmol/L比(43.25±6.99) mmol/L],血肌酐和血清钾显著降低[(42.83±1.51) μmol/L比(66.22 ±6.03) μmol/L; (4.69±0.21) mmol/L比(5.57±0.37) mmol/L].AQP2表达BUO组显著低于Sham组,TEL组显著高于BUO组,各组比较差异有统计学意义(P<0.05).结论 替米沙坦可抑制AQP2蛋白表达下调,减轻BUO解除后肾脏低渗性尿,保护肾脏功能.
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Key words
Ureteral obstruction,Aquaporin 2,Telmisartan,Renal function
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