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Expression of COX-2 mRNA in rat aortic endothelial cells in high glucose environment

Ying-li Lu,Ting-ting Ye,Hua Yang,Yi Chen,Jiao Yu, Li-juan Zhao,Fang-zhen Xia,Ning-jian Wang,Chao Shi,Jie Qiao,Lin Ye,Dong-ping Lin,Wan-ling Wu

Chinese Journal of Endocrinology and Metabolism（2009）

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Abstract
The expression of cyclooxy genase-2 (Cox-2) in endothelial cells (ECs) was determined. These cells were from aorta of diabetic rat and SD rats, cultured in vitro with high glucose. High glucose increased COX-2 mRNA expression both in rat aortic ECs cultured in vitro and in vivo,which was inhibited by aspirin treatment.\r\n\r\nKey words: \r\nAorta;  Endothelial cells;  High glucose;  COX-2 ;  Aspirin
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Prostaglandin E2
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