Phase I/Ii Study Of T-Dm1 Alone Versus T-Dm1 And Metronomic Temozolomide In Secondary Prevention Of Her2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

Alexandra S. Zimmer,Brunilde Gril,Seth Steinberg,Deedee Smart,Mark Gilbert,Teri Armstrong,Lin Xiao,Nicole Houston,Nadia Biassou,Priscilla Brastianos,Scott Carter,David C. Lyden,Stanley Lipkowitz,Patricia Steeg

JOURNAL OF CLINICAL ONCOLOGY（2018）

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摘要

TPS2572Background: We demonstrated that low doses of temozolomide (TMZ) administered in a prophylactic, metronomic fashion significantly prevented development of brain metastases in murine models o...

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stereotactic radiosurgery,breast cancer

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