Effects of Tianma-Sanqi Decoction on blood pressure variability of hypertensive patients with anxiety

Objective To observe the efficacy of modified Tianma-Sanqi Decoction on hypertension patients with anxiety. Methods Totally 64 hypertension patients with anxiety patients were randomly divided into control group (32 cases) and treatment group (32 cases). The control group with standard medications for hypertension and treatment group with addition of Tianma-Sanqi Decoction, and both groups were continuously treated for 8 weeks.The changes of 24 hours ambulatory blood pressure and SAS scores were compared. Results (1) After treatment in the control group and treatment group of 24 h mean systolic blood pressure (24 hSBP) ((130.13±3.81)mmHg, (123.56±4.37)mmHg) (1 mmHg=0.133 kPa) were lower than before treatment((145.36±7.17) mmHg, (145.16±6.77) mmHg) and the difference was statistically significant(P<0.01). (2) After treatment in the control group and treatment group 24 h systolic pressure standard deviation, diurnal systolic pressure standard deviation and nocturnal systolic pressure standard deviation((12.19±3.21) mmHg, (11.16±2.26) mmHg, (10.49±3.76) mmHg and (10.95±2.35) mmHg, (10.08±2.67) mmHg, (10.12±3.78)mmHg) were lower than before treatment ((14.53±3.65) mmHg, (13.81±4.04) mmHg, (12.47±4.23) mmHg and (16.73±7.90)mmHg, (16.06±4.14)mmHg, (13.65±4.92)mmHg), and the difference was statistically significant(P<0.01 or P<0.05). After treatment in the treatment group, 24 h systolic pressure standard deviation, nocturnal systolic pressure standard deviation ((10.95±2.35) mmHg, (10.08±2.67) mmHg) were lower than control group((12.19±3.21) mmHg, (11.16±2.26) mmHg) and the difference was statistically significant.(P<0.01). (3) After treatment in the treatment group, SAS scores (36.68±3.88) points were lower than before treatment (58.66±3.13) points and the difference was statistically significant(P<0.01). After treatment the SAS score ((36.68±3.88) points) in the treatment group was lower than control group((51.86+ 2.62) points). Conclusion The hypertension patients with anxiety treated with Tianma-Sanqi Decoction and benazapril can improve blood pressure variability and the symptoms of anxiety. Key words: Tianma-Sanqi Decoction; Hypertension; Anxiety; Blood pressure variability