Su1657 IN AN INDIVIDUAL WITH PRIMARY BILIARY CHOLANGITIS TREATED WITH OBETICHOLIC ACID, THE PROBABILITY OF PRURITUS IS HIGHER THAN THAT OF A CLINICAL RESPONSE, BUT PRURITUS IS LESS LIKELY TO BE ATTRIBUTABLE TO THE DRUG.

to assess if the patients were prescribed regimens of rotating antibiotics for PSC.The specific activity scores that were calculated include Mayo Score for UC Activity, Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and Crohn's Disease Activity Index (CDAI).Univariate and multilinear regression models were utilized for data analysis.Results: A total of 69 PSC patients had a diagnosis of IBD, 50 of which having UC and 19 having Crohn's Disease (CD).In total, 29/50 (58.0%) patients were found to have active UC (Mayo Score greater than 0), and 6/19 (31.6%) were found to have active CD.27/69 (39.1%) patients were prescribed rotating antibiotics for their PSC.The mean Mayo Score for UC was 1.24±2.64for the group who received antibiotics, 6.32±3.84 for the group who did not receive antibiotics, and 4.14±4.20 overall.In a multilinear analysis controlling for sex and ages at the time of diagnoses, we found that rotating antibiotic administration was associated with a decreased Mayo Score for UC activity.On average, the patients who were on rotating antibiotics had 4.87 points less than patients not treated with rotating antibiotics (p<0.001,CI [-6.74, -2.83]).Additionally, logistic regression revealed a significant association between rotating antibiotic administration and quiescent UC disease (OR=0.032,CI [0.005-0.196],p<0.001).Conclusion: In a single center long term follow-up study, our findings show that PSC patients with UC were less likely to have active UC disease if they were on rotating antibiotics, as well as a significant decrease in disease severity, based on the Mayo Score Disease Activity Index.Further studies are needed to understand how the altered microbiome for these patients on rotating antibiotics directly impacts the disease course for patients with PSC-IBD. Su1654