Who2016 Vs. Who2008 Criteria For The Diagnosis Of Chronic Myelomonocytic Leukemia

The new WHO2016 diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (≥1×109/L and ≥10% of the WBC count) in peripheral blood (PB). In addition, they say that the presence of myeloproliferative neoplasms (MPN) features in the bone marrow (BM) and/or MPN-associated mutations (JAK2, CALR, or MPL) tend to support MPN with monocytosis rather than CMML. This study was performed to predict impact of the WHO2016 criteria in the diagnosis of CMML compared to the WHO2008 criteria.