Serial Shunt Evaluation Reveals Limitations of Contemporary Screening Studies for Patent Foramen Ovale.

JACC: Cardiovascular Interventions(2020)

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Abstract
Percutaneous closure of a patent foramen ovale (PFO) reduces stroke in appropriately selected patients ([1][1]). PFO screening typically employs agitated saline injection into the brachiocephalic vein, which drains via the superior vena cava (SVC) to the right atrium. Bubbles bypassing the lungs are
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