INHIBITION OF HUR ASSOCIATION WITH CX43 MRNA IMPAIRS INTESTINAL EPITHELIAL BARRIER FUNCTION AFTER POLYAMINE DEPLETION

expression between indolent and progressed biopsies: mainly fatty acid metabolism downregulation and early signs of DNA damage and immune infiltration.Conclusions We show BE to be a continuum of abnormalities in the progression to cancer, punctuated by certain key genomic alterations.We move away from current phenotypic grading and hypothesize that it is the accumulation of events that tip the balance to progression.