A Co(II) coordination polymer: enhanced fentanyl analgesic activity via reducing glutamate receptor expression

A new Co(II)-containing coordination polymer formulated as [Co(H-ntb)](n) (1) has been synthesized via reaction of Co(NO3)(2)center dot 6H(2)O with the 4,4 ',4 "-nitrilotribenzoate (H(3)ntb) ligand under solvothermal conditions. In addition, the enhancement of the compound on Fentanyl analgesic activity was evaluated. First, the RT-PCR was carried out to assess the glutamate receptor relative expression level on sympathetic nerve cells. Then, the mouse hot plate analgesic experiment was performed for the evaluation of the enhancement of the compound on Fentanyl analgesic activity. In the end, molecular docking simulation has been performed to investigate the possible interactions between the probe protein and the Co(II) complex.