Transcranial Random Noise Stimulation for the Acute Treatment of Depression: A Randomized Controlled Trial

Transcranial electrical stimulation has potential as a treatment for depression. Modification of stimulation parameters to improve neuromodulatory effects can theoretically improve efficacy. Transcranial random noise stimulation (tRNS) delivers randomly fluctuating current intensities and may have greater cortical excitatory effects compared to other forms of transcranial electrical stimulation. It may, therefore, produce enhanced antidepressant effects.