Association of adenylate cyclase-2 gene polymorphism with bipolar disorder.

•We examined genetic contributions to investigate the association between ADCY-2 gene polymorphism and Bipolar Disorder.•We found that the rs2892609, rs4702484, rs1460970, and rs326149 polymorphism of the ADCY-2 gene were associated with BPD.•This study indicates that ADCY-2 gene is a susceptibility gene of bipolar disorder.