CYP2D6 Revisited in GENDEP: Inter-Platform Concordance

Katherine Aitchison,Beatriz Carvalho Henriques,Vasyl Yavorskyy,Yabing Wang,Kristina Martens,Bahareh Behroozi Asl,Michael Carr,Joshua Hague,Xiuying Hu,Wolfgang Maier,Mojca Z. Dernovsek,Neven Henigsberg, Daniel Souery, Annamaria Cattaneo,Ole Mors,Marcella Rietschel,Cathryn Lewis,Gerald Pfeffer,Chad Bousman

Biological Psychiatry（2020）

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摘要

Despite guidelines indicating potential clinical utility of genotyping for CYP2D6, this is not yet routinely provided. A contributing factor to this is the complexity of the locus including “structural variants” (complete or partial gene deletions and duplications).

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关键词

Antidepressant,CYP2D6,CYP2C19,Pharmacogenomics

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