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A fast DLLME-LC-MS/MS method for risperidone and its metabolite 9-hydroxyrisperidone determination in plasma samples for therapeutic drug monitoring of patients

Greyce Kelly Steinhorst Alcantara,Leandro Augusto Calixto,Bruno Alves Rocha,Fernando Barbosa Júnior,Anderson Rodrigo Moraes de Oliveira,Cristiane Masetto de Gaitani

Microchemical Journal（2020）

Cited 7|Views16
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Abstract
•Fast and simple method for risperidone and its metabolite analysis in human plasma.•The method is based on DLLME and liquid chromatography-tandem mass spectrometry.•This method was successfully applied for plasma analysis of schizophrenic patient.
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Risperidone,9-hydroxyrisperidone,DLLME-LC-MS/MS,Human plasma,Therapeutic drug monitoring
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