Biophysical and Morphological Changes in Inner Hair Cells and Their Efferent Innervation in the Ageing Mouse Cochlea
Journal of Physiology(2020)
摘要
Age‐related hearing loss is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age‐related changes in inner hair cells (IHCs) between four mouse strains with different levels of progressive hearing loss. The surface area of apical coil IHCs (9–12 kHz cochlear region) decreases by about 30–40% with age. The number of BK channels progressively decreases with age in the IHCs from most mouse strains, but the basolateral membrane current profile remains unchanged. The mechanoelectrical transducer current is smaller in mice harbouring the hypomorphic Cdh23 allele Cdh23ahl (C57BL/6J; C57BL/6NTac), but not in Cdh23‐repaired mice (C57BL/6NTacCdh23+), indicating that it could contribute to the different progression of hearing loss among mouse strains. The degree of efferent rewiring onto aged IHCs, most likely coming from the lateral olivocochlea fibres, was correlated with hearing loss in the different mouse strains.
更多查看译文
关键词
auditory brainstem responses,C3H,HeJ mice,C57BL,6 mice,cadherin 23,cochlea,hair cells,hearing loss,mechanoelectrical transduction,olivocochlear efferent fibres,potassium currents
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要