Mini-review - Sodium channels and beyond in peripheral nerve disease: Modulation by cytokines and their effector protein kinases

•Nav1.7, Nav1.8, and Nav1.9 are associated with peripheral human pain disorders.•Peripheral neuropathy engages multiple signaling pathways and activates multiple kinases.•Inflammatory mediators control VGSC expression and gating which contributes to pain.•VGSCs are phosphorylated by kinases which are activated by inflammatory mediators.