Modeling Leukemia Stem Cells with Patient-Derived Induced Pluripotent Stem Cells.

André G Deslauriers,Andriana G Kotini,Eirini P Papapetrou

Methods in molecular biology (Clifton, N.J.)（2021）

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摘要

Patient-derived induced pluripotent stem cells (iPSCs) have recently provided a new way to model acute myeloid leukemia (AML) and other myeloid malignancies. Here, we describe methods for the generation of patient-derived iPSCs from leukemia cells and for their subsequent directed in vitro differentiation into hematopoietic cells that recapitulate features of leukemia stem cells (LSCs) and leukemic blasts.

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关键词

AML,Human induced pluripotent stem cells,Reprogramming,hPSC-hematopoiesis,iPSC disease modeling

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