Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse

Qumar Zaman,Ranjha Khan,Uzma Hameed,Wasim Shah,Ahmed Waqas,Muhammad Zubair,Sobia Dil, Tuba Zafar,Asim Ali,Ahsanullah Unar,Qinghua Shi

Gene（2021）

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摘要

•CRISPR/Cas9 mediated Exo5-/- mouse is fertile.•Histological and meiotic analysis of Exo5-/- mice displayed no variations.•Cytological analysis showed normal synaptonemal complex formation, synapsis, recombination and DSBs repair.

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关键词

Exo5,Spermatogenesis,Fertility,Mismatch repair

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