Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway

Yuan Liang,Tiehua Zhang,Li Ren,Siyuan Jing,Zhuolin Li,Peng Zuo,Tiezhu Li, Yongjun Wang,Jie Zhang,Zhengyi Wei

Environmental Toxicology and Pharmacology（2021）

Cited 23|Views22

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Abstract

•Cucurbitacin IIb (CuIIb) exhibited the proliferation inhibitory activity in A549 cells.•CuIIb induced apoptosis via STAT3 pathway.•CuIIb suppressed the cell cycle and resulted G2/M phase cell cycle arrest.•Leu694 and Met769 are key amino acids for EGFR-CuIIb binding.•CuIIb inhibited the kinase activity of EGFR and may serve as a potential EGFR TKI.

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Key words

Cucurbitacin IIb (CuIIb),Epidermal growth factor receptor (EGFR),Tyrosine kinase inhibitor (TKI),Apoptosis,Cell cycle arrest,Binding mode

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