Congenital chagas disease: Development and assessment of a specific IgM capture-based assay for diagnosis of transmission

Luz María Peverengo,Luz María Rodeles, Camila Maldonado,Griselda Ballering,Nazarena Pujato,Indira D'Amico,Miguel Hernán Vicco,Luciana Garcia,Laura Jurado,Jaime Altcheh,Iván Marcipar

Acta Tropica（2021）

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摘要

•The ELISA technique developed was based on the capture of specific anti-Trypanosoma cruzi IgM antibodies and able to detect them accurately on infected newborns samples.Remarkable performance has been achieved using the new CP4 chimeric recombinant antigen.•This technique can certainly improve the diagnosis of connatal infection for Chagas disease.

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Congenital,Chagas Disease,Diagnosis,IgM,capture assay

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