A NEW INFLAMMATORY MARKER ASSOCIATED WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: PLATELET TO ALBUMIN RATIO

Background: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by disordered immunity and dysregulated cytokine. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been defined as inflammatory markers to evaluate disease activity of RA. Recently, platelet to albumin ratio (PAR) was reported as a new prognostic index in patients with cancer. However, similar studies have not been displayed in RA. Objectives: This study was to explore the role of PAR in RA and its association with disease activity. Methods: This retrospective study enrolled 136 RA patients and 87 age- and gender-matched healthy controls. Neutrophil, lymphocyte, monocyte, platelet, hemoglobin, albumin, NLR, neutrophil to hemoglobin ratio (NHR), neutrophil to albumin ratio (NAR), monocyte to lymphocyte ratio (MLR), monocyte to hemoglobin ratio(MHR), monocyte to albumin ratio(MAR), PLR, platelet to hemoglobin ratio (PHR), PAR, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and Disease Activity Score of 28 joints - ESR (DAS28-ESR) were detected. Receiver operation characteristic (ROC) curve was used to discriminate RA patients from healthy individuals. Relationships between PAR and DAS28-ESR as well as other laboratory data were measured by the Spearman’s correlations analysis. Results: RA patients showed higher levels of NLR, NHR, NAR, MLR, MHR, MAR, PLR, PHR PAR and lower levels of albumin than healthy controls. PAR and other inflammatory parameters were also raised along with increased disease activity in RA patients (P Conclusion: This study demonstrated that PAR was elevated in RA patients and increased with the disease activity. PAR may be a novel marker to assess the disease activity of RA patients. References: [1]Li C, Peng W, Zhang X Y, et al. The preoperative platelet to albumin ratio predicts the prognosis of hepatocellular carcinoma patients without portal hypertension after liver resection[J]. Medicine, 2019, 98:e17920. Acknowledgments: Science and Technology Project of Haizhu District (No.Hai ke gong shang xin ji 2018-89), Youth Foundation of Guangdong Second Provincial General Hospital (No. YQ2017-009). Disclosure of Interests: None declared