CLINICAL SIGNIFICANCE OF LIPID PROFILES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS

Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the sacroiliac joints and spine. Lipid profiles, including total cholesterol(TC), high-density lipoprotein cholesterol(HDL-c), low-density lipoprotein cholesterol (LDL-c), TC/HDL-c, triglycerides(TG), have been reported to be changed regularly in axSpA patients. However, the clinical significance of lipid profiles in axSpA patients is controversial. Objectives: The study aims to determine the clinical significance of TC, HDL-c, LDL-c, TC/HDL-c, TG for axSpA patients. Methods: A total of 208 axSpA patients and 113 healthy subjects were enrolled in the study retrospectively. TC, HDL-c, LDL-c, TC/HDL-c, TG, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) were collected. AxSpA patients were divided into remission axSpA group(BASDAI Results: TC, HDL-c, and TG in axSpA group were lower than those of control group, while TC/HDL-c was higher (P Conclusion: HDL-c was decreased in axSpA patients with a highest diagnostic value, compared with healthy control. TC/HDL-c was elevated in active axSpA patients, showing a significant correlation to the disease activity of axSpA. References: [1]Gluszko P, Bonek K, Rupinski R, et al. LIPID PROFILE AND ACTIVE SYSTEMIC INFLAMMATION MAY DIFFERENTLY AFFECT THE PATHOMECHANISM OF CARDIOVASCULAR DISORDERS IN ANKYLOSING SPONDYLITIS (AS) AND IN PSORIATIC ARTHRITIS (PSA)[J]. ANNALS OF THE RHEUMATIC DISEASES. 2016: 1146. Acknowledgments: This study was supported by Science and Technology Project of Guangzhou Haizhu District (Haike Business Infox 2018-89). Disclosure of Interests: None declared