188P Impact of HIV infection (HIV+) on baseline characteristics and survival of breast cancer (BC) patients (pts): A systematic review and meta-analysis

The number of HIV+ women diagnosed with BC is increasing. Yet, data are conflicting regarding their stage at diagnosis, distribution of BC subtypes and prognosis. We aimed to assess differences in baseline characteristics and overall survival (OS) between HIV+ vs HIV-uninfected (HIV-) BC pts. Systematic review using MEDLINE, Scielo and conference abstracts (hand search of studies presented in major meetings) up to 1 Jan 2020 with no language restrictions was performed. Cross-sectional or cohort studies comparing baseline characteristics (mean age, stage or BC subtypes) or OS of HIV+ vs HIV- BC pts were included. Main endpoints were age, late stage at diagnosis, proportion of subtypes and OS. Subgroup analyses were performed according to world region. Other endpoints were detailed stage and estrogen receptor (ER) status. Summary estimates (pooled mean age ratios [MR], odds ratios [OR] and hazard ratios [HR]) were calculated using random effects models. 20 publications (5 from North America, 15 from Sub-Saharan Africa [SSA]) were included, with 3,174 HIV+ and 2,394,598 HIV- pts. Mean age was 18% lower among HIV+ pts vs HIV- pts (MR 0.82, 95% CI 0.76-0.89) and HIV+ pts had a 53% increased risk of presenting with late stage BC (OR 1.53, 95% CI 1.37-1.71). HIV+ pts had smaller odds of having ER+/HER2- BC, but there were no differences regarding other subtypes (Table). HIV+ pts had a 90% increased risk of dying compared to HIV- pts (adjusted HR 1.90, 95% CI 1.21-2.99), with similar results in North America and SSA.TableHIV+ ptsHIV- ptsPooled estimate (95% CI)PAgeAll144316MR 0.82 (0.76-0.89)