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Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

Felix A. Dingler,Meng Wang,Anfeng Mu,Christopher L. Millington, Nina Oberbeck,Sam Watcham,Lucas B. Pontel,Ashley N. Kamimae-Lanning,Frederic Langevin, Camille Nadler,Rebecca L. Cordell,Paul S. Monks,Rui Yu,Nicola K. Wilson,Asuka Hira,Kenichi Yoshida,Minako Mori,Yusuke Okamoto,Yusuke Okuno,Hideki Muramatsu,Yuichi Shiraishi,Masayuki Kobayashi,Toshinori Moriguchi,Tomoo Osumi,Motohiro Kato,Satoru Miyano,Etsuro Ito,Seiji Kojima,Hiromasa Yabe,Miharu Yabe,Keitaro Matsuo,Seishi Ogawa,Berthold Goettgens,Michael R. G. Hodskinson,Minoru Takata,Ketan J. Patel

Molecular Cell（2020）

Cited 113|Views62
Key words
hematopoietic stem cells,hematopoiesis,bone marrow failure,immunodeficiency,formaldehyde,oncometabolite,ageing,DNA damage,mutagenesis,cancer
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