-Arrestins in liver disease

We read with interest the Letter by Schierwagen et al. (1), which reports that fibrotic liver injury in rodents and in patients is associated with increased whole liver expression of β-arrestin 2 (β-Arr2), appearing to contrast with our recent report (2) demonstrating that injury induced by bile duct ligation (BDL) in mice leads to decreased β-Arr2 expression in liver sinusoidal endothelial cells (LSECs). We demonstrated that reduced β-Arr2 expression in this specific cell type is associated with reduced activation of endothelial nitric oxide synthase and portal hypertension.\n\nWe find that whole liver β-Arr2 appears to be unchanged to slightly elevated (although not statistically so) after BDL in rats and mice (Fig. 1). However, we emphasize that the finding of changes in whole liver … \n\n[↵][1]1To whom correspondence may be addressed. Email: rockey{at}musc.edu.\n\n [1]: #xref-corresp-1-1