General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Yulim Lee,Jun Young Heo,Xianshu Ju,Jianchen Cui,Min Jeong Ryu,Min Joung Lee,Boohwi Hong,Sungho Yoo,Jeonghoon Ahn,Yoon Hee Kim,Youngkwon Ko,Woosuk Chung

NeuroToxicology（2021）

引用 8|浏览15

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摘要

•A 2 -h sevoflurane exposure induces age-dependent mitochondrial changes in young mice.•Blocking mitochondrial upregulation prevents sevoflurane-induced synaptic changes.•Sevoflurane activates the mitochondrial unfolded protein response (UPRmt) in young mice.•Mitochondria and UPRmt are potential targets for anesthesia-induced neurotoxicity.

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关键词

General anesthesia,Mitochondria respiration,Neurodevelopment,Neurotoxicity,Synaptic transmission,Unfolded protein response

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